Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity.
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity.
alpha, beta-Unsaturated carbonyl compounds are important not only from a theoretical but also a practical standpoint. These ubiquitous compounds can interact with DNA through various mechanisms. The predominant interaction is the formation of cyclic 1,N2-deoxyguanosine adducts; 7,8-cyclic guanine adducts are also found. We have synthesized and characterized the stereoisomers of adducts formed b...
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*Correspondence: Takashi Yagi, Laboratory of Molecular and Cellular Genetics, Department of Biology, Graduate School of Science and Radiation Research Center, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan e-mail: [email protected] Formaldehyde is commonly used in the chemical industry and is present in the environment, such as vehicle emissions, ...
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Hepatotoxicity represents a serious adverse health effect caused by a number of xenobiotic chemicals. This effect is generally detected at the later stages of drug development or with in vivo (whole animal) studies. Both the chemical structure and reactivity of an organic compound have significant impact on its mode of action, and, hence, the anticipated hepatotoxic effects. Currently, there is...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1990
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.908899